REVERSIBLE INACTIVATION OF TYPHUS RICKETTSIAE
نویسندگان
چکیده
منابع مشابه
Reversible Inactivation of Typhus Rickettsiae
Rickettsiae that have been frozen and thawed in isotonic salt solutions show greatly decreased toxicity for mice, hemolytic activity, respiration, and infectivity for eggs. All these properties can be partially restored by incubation of the rickettsiae in the presence of DPN and coenzyme A for 2 hours at 34 degrees C. The extent of both inactivation and of subsequent reactivation is markedly af...
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Partially purified suspensions of typhus rickettsiae have been shown to exhibit metabolic activity as evidenced by consumption of oxygen and production of carbon dioxide in the presence of glutamate. Similar activity at a much lower rate occurs in the presence of pyruvate. The rate of oxygen uptake was directly proportional to the concentration of viable rickettsiae, as estimated by their toxic...
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The rickettsiae have always been difficult to study because convenient titration and isolation techniques have not been available for the study of these organisms. In recent reports (3, 5), however, we demonstrated the use of a sensitive plaque test for measuring concentrations of typhus and spotted fever rickettsiae. Studies were then initiated to determine whether this assay system is appropr...
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However, rather than suggesting that a single case report “contradicts” the anterior horn cell hypothesis, we suggest that WNV-associated flaccid paralysis be viewed as having a spectrum of causes, one of which certainly is poliomyelitis like illness. The neuropathologic findings in poliomyelitis (due to poliovirus, WNV, or other viruses) are not restricted focally to the anterior horn cells (5...
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Six proteins, previously established as major constituents of intact organisms, were identified in cell envelopes obtained from intrinsically radiolabeled Rickettsia prowazekii. Extrinsic radioiodination of intact organisms conducted at 0.5 micronM iodide indicated that protein 4 was the most peripheral, although protein 1 also had reactive groups exposed on the surface of the organisms. A 10-f...
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ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 1954
ISSN: 1540-7748,0022-1295
DOI: 10.1085/jgp.38.2.169